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Home Antibody All anti-INS antibodies

Anti-INS Antibody polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA327695
  • Guinea pig Polyclonal Insulin Antibody
0.1ml 325 3-7 Days
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IHC(1)
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Also for INS (NM_000207)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen
Clone Namepolyclonal Isotype
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsIHC: 1:100 - 1:500
BufferThe antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
Purification Affinity purification
Note Insulin is a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Immunohistochemical investigations have localized insulin in the beta cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of beta cell origin such as insulinoma.Anti-insulin staining in the cytoplasm of tumors is the most reliable indication of functional insulinomas.

Reference Data

Target NameHomo sapiens insulin (INS), transcript variant 1
Alternative NameIDDM1; IDDM2; ILPR; IRDN; MODY10
Database LinkNP_000198
Entrez Gene 3630 Human
Function
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome Oocyte meiosisRegulation of autophagymTOR signaling pathwayRegulation of actin cytoskeletonInsulin signaling pathwayProgesterone-mediated oocyte maturationMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry staining of Paraffin Pancreas tissue by Insulin antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic)

 

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