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Home Antibody All anti-INPP5D antibodies

Anti-INPP5D Antibody EP378Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303547
  • Rabbit monoclonal antibody against SHIP(EP378Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417234) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for INPP5D (NM_005541)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Clone NameEP378Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50,000; IHC: 1:100-250; FC: 1:20; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2
Alternative Namehp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Database LinkNP_005532
Entrez Gene 3635 Human
FunctionThis gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Related Pathway
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - SHIP antibody [EP378Y]; Anti-SHIP antibody [EP378Y] at 1/50000 dilution + Daudi cell lysate at 10 ug.Secondary.Goat anti-rabbit, HRP labelled at 1/2000 dilution.Predicted band size : 133 kDa.Observed band size : 140 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SHIP antibody [EP378Y]; Ab45142 at 1/100 staining SHIP in human spleen by immunohistochemistry using paraffin embedded tissue.

 

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