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Anti-INPP5D Antibody EP378Y
Also for INPP5D (NM_005541)
|A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50,000; IHC: 1:100-250; FC: 1:20; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2|
|hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145|
Entrez Gene 3635 Human
|This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
|Druggable Genome Phosphatidylinositol signaling systemB cell receptor signaling pathwayFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisInsulin signaling pathway|
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Western blot - SHIP antibody [EP378Y]; Anti-SHIP antibody [EP378Y] at 1/50000 dilution + Daudi cell lysate at 10 ug.Secondary.Goat anti-rabbit, HRP labelled at 1/2000 dilution.Predicted band size : 133 kDa.Observed band size : 140 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SHIP antibody [EP378Y]; Ab45142 at 1/100 staining SHIP in human spleen by immunohistochemistry using paraffin embedded tissue.