Home Antibody All anti-IL34 antibodies
Also for IL34 (NM_001172771)
|IL-34 antibody was raised against a 13 amino acid peptide from near the center of human IL-34.|
|Human, Mouse, Rat
||WB: 0.25 - 0.5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 34 (IL34), transcript variant 2|
Entrez Gene 146433 Human
Entrez Gene 76527 Mouse
Entrez Gene 498951 Rat
|Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages. Despite its predicted molecular weight, IL-34 will often run at higher molecular weight in SDS-PAGE.|
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Western blot analysis of IL-34 in human brain tissue lysate with IL-34 antibody at 0.25 µg/ml in (A) the absence and (B) the presence of blocking peptide.