Home Antibody All anti-IL27RA antibodies
Also for IL27RA (NM_004843)
|TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human TCCR precursor.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens interleukin 27 receptor, alpha (IL27RA)|
|CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1|
|Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned (1,2). It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1 (1,2). TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a . TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.|
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Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 ug /ml.
Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 ug/ml.