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Anti-IL22 Antibody EPR5740


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against IL-22 (IL22)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412429) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human IL-22 was used as an immunogen.
Clone NameEPR5740 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens interleukin 22 (IL22)
Alternative NameIL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa; TIFIL-23; zcyto18
Database LinkNP_065386
Entrez Gene 50616 Human
FunctionInterleukin-22 (IL-22), an IL-10 family cytokine, is expressed in activated T cells, Th1 cells and NK cells (1, 2). IL-22 induces expression of various antimicrobial peptides such as ß-defensins in skin, respiratory, and digestive tissues, which express IL-22R (1). It also mediates the crosstalk between leukocytes and tissue epithelia because its receptor is preferentially expressed on various tissue epithelial cells. IL-22 is essential for host defense against infections of extracellular pathogens, such as bacteria and yeasts, by eliciting various innate defensive mechanisms from tissue epithelial cells and promoting wound-healing responses (2). Enhanced IL-22 levels have been linked to various states of immunoactivation as seen in the context of infection, autoimmunity, and allergic disorders (3).
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-IL22 antibody [EPR5740]; Anti-IL22 antibody [EPR5740] at 1/1000 dilution + Recombinant Human IL22 at 0.01 ug.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 14 kDa.Observed band size : 20 kDa .
Other-Anti-IL22 antibody [EPR5740](TA310623); Equilibrium disassociation constant (KD)..


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