Home Antibody All anti-IL1RAP antibodies
Also for IL1RAP (NM_001167928)
|IL-1RAcP antibody was raised against a peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins.|
||WB: 1:1000 - 1:2000
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 1 receptor accessory protein (IL1RAP), transcript variant 3|
|C3orf13; IL-1RAcP; IL1R3|
|The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NFkappa-B inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP (2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.|
Cytokine-cytokine receptor interaction
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Western blot analysis of IL-1RAcP in HeLa whole cell lysate with IL-1RAcP antibody (C2) at 1:1000 dilution.