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Home Antibody All anti-IL1B antibodies

Anti-IL1B Antibody EP408Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310621
  • Rabbit Monoclonal antibody against IL-1 beta (C-term) (IL1B)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400196) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for IL1B (NM_000576)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen
Clone NameEP408Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens interleukin 1, beta (IL1B)
Alternative NameIL-1; IL1-BETA; IL1F2
Database LinkNP_000567
FunctionInterleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).
Related Pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
MAPK signaling pathway
Toll-like receptor signaling pathway

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Anti-IL1 beta antibody [EP408Y] (TA310621) at 1/5000 dilution + approximately 0.05µg of recombinant IL1 beta

 

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