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Home Antibody All anti-IL17A antibodies

Anti-IL17A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319155
  • Rabbit polyclonal anti-IL-17A antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400795) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for IL17A (NM_002190)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIL-17A Antibody was prepared from whole rabbit serum produced by repeated immunizations with full length recombinant human IL17-A protein.
Clone Name IsotypeIgG
Species Reactivityhuman Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:1,000 - 1:5,000, WB: 1:500 - 1:2,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note IL17-A (also known as Interleukin-17) is a pro-inflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL17-A is the founding member of a group of cytokines called the IL-17 family. IL17-A was originally identified as a transcript from a rodent T-cell hybridoma. To elicit its functions, IL17 binds to a type I cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. Anti-IL-17A antibody is ideal for investigators involved in cytokines, growth factors, cancer, and Immunology research.

Reference Data

Target NameHomo sapiens interleukin 17A (IL17A)
Alternative NameCTLA8; IL-17; IL-17A; IL17
Database LinkNP_002181
Function
Related Pathway
Cytokine-cytokine receptor interaction

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WB Image
Western blot using anti-Human IL17-A antibody shows detection of a band ~17 kDa in size corresponding to recombinant human IL17-A (lane 1). Molecular weight markers are also shown (M). After transfer, the membrane was blocked overnight with 3% BSA in TBS followed by reaction with primary antibody at a 1:1,000 dilution. Detection occurred using DyLight 649 conjugated anti-Rabbit IgG (p/n 611-143-122) secondary antibody diluted 1:20,000 in blocking buffer (p/n MB-070). Image was captured using VersaDoc™ MP 4000 imaging system (Bio-Rad).

 

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