Home Antibody All anti-IL12RB1 antibodies
Also for IL12RB1 (NM_005535)
|Recombinant fragment corresponding to a region within amino acids 57 and 488 of IL12 Receptor beta1 (Uniprot ID#P42701)|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1|
|CD212; IL-12R-BETA1; IL12RB; IMD30|
Entrez Gene 3594 Human
|The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway|
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Sample(30 ug whole cell lysate). A:A431. 7.5% SDS PAGE. TA308386 diluted at 1:1000