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Home Antibody All anti-IL12A antibodies

Anti-IL12A Antibody EP5737

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310616
  • Rabbit Monoclonal antibody against IL-12 alpha (IL12A)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC431035) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for IL12A (NM_000882)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human IL-12 alpha was used as an immunogen.
Clone NameEP5737 IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:100 - 1:500
BufferDoes not react with Rat. Is unsuitable for ICC or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens interleukin 12A (IL12A)
Alternative NameCLMF; IL-12A; NFSK; NKSF1; P35
Database LinkNP_000873
Entrez Gene 3592 Human
Entrez Gene 16159 Mouse
FunctionIL-12 alpha is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit protein (IL-12 alpha), and a 40-kD subunit (IL-12 beta) that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity (1).
Related PathwaySecreted ProteinDruggable Genome Cytokine-cytokine receptor interactionToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayJak-STAT signaling pathwayType I diabetes mellitusAllograft rejectionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-IL12A antibody [EP5737]; All lanes : Anti-IL12A antibody [EP5737] at 1/1000 dilution.Lane 1 : NIH3T3 cell lysate.Lane 2 : HuT-78 cell lysate.Lane 3 : Raw 264.7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 25 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL12A antibody [EP5737]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling IL12A with TA310616 antibody at 1/250 dilution.

 

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