Home Antibody All anti-IKBKB antibodies
Also for IKBKB (NM_001556)
|IKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid.|
||ELISA, WB: 0.5 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB), transcript variant 1|
|IKK-beta; IKK2; IKKB; NFKBIKB|
|Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, and bacteria product LPS. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta). IKKalpha and IKKbeta interact with each other and both are essential for NF-kappaB activation. IKKbeta phosphorylates both IkappaB-alpha and IkappaB-beta. IKKbeta is expressed in variety of human tissues.|
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot analysis of IKK beta in Jurkat whole cell lysate with IKK beta antibody (C3) at 1:500 dilution.
Immunocytochemistry staining of HeLa cells using IKK beta antibody at 10 ug/mL.