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Home Antibody All anti-IKBKB antibodies

Anti-IKBKB Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305996 Rabbit Polyclonal IKK beta Antibody 100ug $325 3-7 Days
LC419865 IKBKB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for IKBKB (NM_001556)
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OriGene Data

ImmunogenIKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 ug/mL, ICC: 10 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB), transcript variant 1
Alternative NameIKK-beta; IKK2; IKKB; IMD15; NFKBIKB
Database LinkNP_001547
Entrez Gene 3551 Human
FunctionNuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, and bacteria product LPS. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IkappaB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta). IKKalpha and IKKbeta interact with each other and both are essential for NF-kappaB activation. IKKbeta phosphorylates both IkappaB-alpha and IkappaB-beta. IKKbeta is expressed in variety of human tissues.
Related PathwayProtein KinaseTranscription FactorsDruggable Genome MAPK signaling pathwayChemokine signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IKK beta in Jurkat whole cell lysate with IKK beta antibody (C3) at 1:500 dilution.

IF Image
Immunocytochemistry staining of HeLa cells using IKK beta antibody at 10 ug/mL.

IF Image
Immunofluorescence of IKK beta in Hela cells with IKK beta antibody at 10 ug/mL.


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