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Anti-IFT57 TRUEMAB Antibody Clone OTI2G3
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for IFT57 (NM_018010)
|Full length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell.|
|WB, IHC, IF
||WB 1:1000, IHC 1:50, IF 1:100,
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens intraflagellar transport 57 (IFT57)|
|ESRRBL1; HIPPI; MHS4R2|
Entrez Gene 55081 Human
|Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1,leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear|
|Druggable Genome Huntington's disease|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IFT57 (RC204116, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IFT57.
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500917, Dilution 1:50)
Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-IFT57 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500917, Dilution 1:50)
Immunofluorescent staining of HepG2 cells using anti-IFT57 mouse monoclonal antibody (TA500917).