Home Antibody All anti-IER3 antibodies
Also for IER3 (NM_003897)
|IEX1 antibody was raised against a 24 amino acid peptide near the center of human IEX1.|
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens immediate early response 3 (IER3)|
|DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1; PRG1|
Entrez Gene 8870 Human
Entrez Gene 15937 Mouse
|IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-a. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappaB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.|
|Druggable Genome |
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Western blot analysis of IEX1 in human brain tissue lysate with IEX1 antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry of IEX-1 in human liver tissue with IEX-1 antibody at 2.5 ug/ml.