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Anti-ICOSLG Antibody EPR6071
Also for ICOSLG (NM_015259)
|A synthetic peptide corresponding to residues in the intracellular domain of human B7-H2 was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens inducible T-cell co-stimulator ligand (ICOSLG), transcript variant 1|
|B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS|
Entrez Gene 23308 Human
|B7-H2, or Inducible costimulator ligand (ICOSL), is a member of the Ig superfamily and belongs to the B7 family of costimulatory molecules. It specifically binds to ICOS, but not to other T cell costimulatory molecules such as CD28 and CTLA-4. B7-H2-ICOS interaction appears to be very important in the expansion of activated T cells and late-phase immune responses (1). B7-H2 enhances the proliferation of both CD4 and CD8 T cells, the secretion of Th1- and/or Th2-type cytokines, and the expression of CD154 (CD40 ligand) on T cells (2). It is expressed constitutively on B lymphocytes and at low levels on monocytes (3). Furthermore, B7-H2-ICOS interaction induces IL-10 production, which plays an important role in reducing immune responses (4).|
|Transmembrane Cell adhesion molecules (CAMs)|
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Western blot - Anti-ICOS Ligand antibody [EPR6071]; All lanes : Anti-ICOS Ligand antibody [EPR6071] at 1/1000 dilution.Lane 1 : HL60 cell lysate.Lane 2 : HuT78 cell lysate.Lane 3 : HUVEC cell lysate, treated with TNF-alpha.Lane 4 : HUVEC cell lysate .Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 33 kDa.
Other-Anti-ICOS Ligand antibody [EPR6071](TA310604); Equilibrium disassociation constant (KD)..