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Anti-HSPH1 Antibody EPR4576
Also for HSPH1 (NM_006644)
|A synthetic peptide corresponding to residues in human HSP105 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt.
|Homo sapiens heat shock 105kDa/110kDa protein 1 (HSPH1), transcript variant 1|
|HSP105; HSP105A; HSP105B; NY-CO-25|
|HSP105alpha and HSP105β are mammalian members of the HSP105/110 family, a diverged subgroup of the HSP70 family (1). It has been reported that two isoforms of HSP105 (HSP105alpha and HSP105β) were both moderately expressed in adrenal, spleen, liver and heart; both increased markedly after heat shock. However, in brain HSP105alpha was characteristically highly expressed over HSP105β, but neither increased after heat shock (2). HSP105 prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly, and it inhibits HSPA8/HSC70 ATPase and chaperone activities (3).|
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Western blot - Hsp105 antibody [EPR4576]; All lanes : Anti-Hsp105 antibody [EPR4576] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Human cerebellum lysate.Lane 4 : MCF-7 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 97 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp105 antibody [EPR4576]; Immunohistochemical analysis of paraffin-embedded human thyroid gland carcinoma tissue labelled with TA307151 at 1/50 dilution.
Immunocytochemistry/ Immunofluorescence - Hsp105 antibody [EPR4576]; Immunofluorescent staining of HeLa cells using TA307151 at 1/100 dilution.