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Home Antibody All anti-HSPB2 antibodies

Anti-HSPB2 Antibody N/A

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326432
  • Rabbit polyclonal HSPB2 (MKBP) Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419871) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
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Also for HSPB2 (NM_001541)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:1000
BufferPBS, 50% glycerol, 0.02% sodium azide
Purification Affinity Purified
Note Detects ~27kDa

Reference Data

Target NameHomo sapiens heat shock 27kDa protein 2 (HSPB2)
Alternative NameHs.78846; HSP27; LOH11CR1K; MKBP
Database LinkNP_001532
Entrez Gene 3316 Human
Entrez Gene 69253 Mouse
Entrez Gene 161476 Rat
FunctionHSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS . MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSps, in that the expression of MKBP is not induced by heat shock . In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction . During stress, these complexes dissolve and MKBPs localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic . HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis .
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MKBP in a rat tissue mix using a 1:1000 dilution of the antibody

 

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