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Home Antibody All anti-HSPB1 antibodies

Anti-HSPB1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302050
  • Rabbit Polyclonal Antibody against HSPB1 (S83)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400587) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for HSPB1 (NM_001540)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S83 of human HSPB1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:50~100; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.

Reference Data

Target NameHomo sapiens heat shock 27kDa protein 1 (HSPB1)
Alternative NameCMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27
Database LinkNP_001531
FunctionIn response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.
Related Pathway
MAPK signaling pathway

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WB Image
(LEFT)Western blot analysis of HSPB1 Antibody (S83) in Hela cell line lysates (35ug/lane). HSPB1 (arrow) was detected using the purified Pab (1:60 dilution). (RIGHT)Western blot analysis of HSPB1(arrow) using rabbit polyclonal HSPB1 Antibody (S83) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HSPB1 gene (Lane 2) (Origene Technologies).

 

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