OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
Home Antibody All anti-HSPA8 antibodies

Anti-HSPA8 Antibody 1F2-H5, Loading Control


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326362 Mouse monoclonal anti-HSPA8(HSC70) antibody, clone 1F2-H5, Loading control 200µg $325 In Stock
LC401978 HSPA8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
Add to Shopping Cart
Write Review & Get Rewarded

Write a review and get rewarded!

Review this antibody and earn an OriGene coupon or Amazon giftcard

Follow these easy steps to reward yourself:

  1. Sign in to your account, or register for a new account;
  2. Write a review;
  3. Receive a coupon or giftcard once your review is accepted.

Click the button to start writing a review

Also for HSPA8 (NM_006597)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHuman Hsc70
Clone Name1F2-H5 IsotypeIgG2a Kappa
Species ReactivityHuman, Mouse, Rat. Not yet tested in other species. Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB 1:1000
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~73kDa. Does not cross react with Hsp70

Reference Data

Target NameHomo sapiens heat shock 70kDa protein 8 (HSPA8), transcript variant 1
Alternative NameHEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71
Database LinkNP_006588
Entrez Gene 3312 Human
Entrez Gene 15481 Mouse
Entrez Gene 24468 Rat
FunctionHsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity . The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides . When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half . The structure of this ATP binding domain displays multiple features of nucleotide binding proteins . When cells are subjected to metabolic stress (e.g., heat shock) a member of the hsp 70 family, hsp 70 (hsp72), is expressed; hsp 70 is highly related to hsc70 (>90% sequence identity). Constitutively expressed hsc70 rapidly forms a stable complex with the highly inducible hsp70 in cells following heat shock. The interaction of hsc70 with hsp 70 is regulated by ATP. These two heat shock proteins move together in the cell experiencing stress. Furthermore, research on hsc70 has implicates it with a role in facilitating the recovery of centrosomal structure and function after heat shock .
Related PathwayStem cell - Pluripotency SpliceosomeMAPK signaling pathwayEndocytosisAntigen processing and presentation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western lot analysis of 1: mix of 10 different human cell lines, 2: Hsp72 recombinant protein, and 3: Hsc70(Hsp73) recombinant protein.


Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title

Notice to Non-US Customers

ExclaimationWeb price and delivery time are for direct sales only.

Non-US customers are encouraged to contact our dedicated distributor network for quotes and streamlined ordering/delivery support.