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Home Antibody All anti-HSP90B1 antibodies

Anti-HSP90B1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326478 Rabbit Polyclonal Anti-Grp94 Antibody 100µg $325 3-7 Days
LC418780 HSP90B1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for HSP90B1 (NM_003299)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to the sequence near the C-terminus of mouse GRP94.
Clone Name Isotype
Species ReactivityHuman, Mouse, Rat, Bovine Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:1000, IP: 1:80
BufferPBS pH 7.4, 0.09% azide.
Purification Peptide Affinity Purified
Note Detects ~94kDa.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa beta family member 1 (HSP90B1)
Alternative NameECGP; GP96; GRP94; HEL-S-125m; HEL35; TRA1
Database LinkNP_003290
Entrez Gene 7184 Human
Entrez Gene 22027 Mouse
Entrez Gene 362862 Rat
FunctionGrp94 (glucose regulated protein 94, gp96) is a constitutively expressed endoplasmic reticulum (ER) lumenal protein that is up-regulated in response to cellular stress such as heat shock, oxidative stress or glucose depletion. Grp94 is thought to play a role in protein translocation to the ER, in their subsequent folding and assembly, and in regulating protein secretion . Grp94 also plays a role in antigen presentation by accessing the endogenous pathway and eliciting specific CTL responses to chaperone bound peptides via MHC class I pathway Grp94 is a member of the Hsp90 family of stress proteins and shares sequence homology with its cytosolic equivalent, Hsp90 . Both Hsp90 and Grp94 are calcium binding proteins . Despite sharing 50% sequence homology over its N domains and complete conservation in its ligand binding domains with Hsp90, Grp94 and Hsp90 differ in their interactions with regulatory ligands as Grp94 has weak ATP binding and hydrolyisis activity .Grp94 exists as a homodimer and the two subunits interact at two distinct intermolecular sites, C terminal dimerization domains and the N-terminal interacts with the middle domain of opposing subunits. . Grp94 contains a carboxy terminal KDEL (Lys-Asp-Glu-Leu) sequence which is believed to aid in its retention in the ER .
Related PathwayDruggable Genome NOD-like receptor signaling pathwayPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
WB of rat brain lysate showing detection of ~94 kDa GRP94 using Anti-GRP94. Load: 20 µg RB lysate per lane. Block: 5% milk + TBST 1hr at RT. Primary antibody: Rabbit Anti-GRP94 polyclonal antibody incubated for 60 min at RT. Secondary antibody: Goat Anti-Mouse HRP antibody at 1:50-1:100 for 60 min at RT. Colour Development: TMB solution for 5 min at RT. Predicted/Observed size: ~ 94-100 kDa. Other band(s): ~50, ~75 kDa.


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