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Home Antibody All anti-HSP90AA1 antibodies

Anti-HSP90AA1 Antibody EPR3953

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SKU Description Amount Price Availability*  
TA307632
  • Rabbit monoclonal antibody against Hsp90 Alpha(clone EPR3953)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400399) , 20ug Explanation
100ul $325 In Stock
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WB(1)
IHC(2)
IF(1)
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Also for HSP90AA1 (NM_001017963)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Hsp90 Alpha was used as an immunogen.
Clone NameEPR3953 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 85 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 1
Alternative NameEL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
Database LinkNP_001017963
Entrez Gene 3320 Human
Entrez Gene 15519 Mouse
Entrez Gene 299331 Rat
FunctionHsp90 Alpha (Heat shock protein 90 alpha) is a cytosolic homodimeric molecular chaperone that modulates the stability and/or transport of a diverse set of critical cellular regulatory, metabolism, organization, and signaling proteins (1). Hsp90 distinguishes itself from other chaperones by having most of its known substrates as signal transduction proteins; e.g. non activated steroid hormone receptors, several proto-oncogenic tyrosine and serine/threonine kinases, and actin (2). These substrates are brought into complex by a multiprotein hsp90/hsp70-based chaperone machinery to function in protein folding (3). Two isoforms correspond to the major and minor isoform, Hsp90 Alpha and Hsp90 Beta. Hsp90 Beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90 Alpha, whereas Hsp90 Alpha is stress-inducible and overexpressed in many cancer cells (4).
Related PathwayDruggable Genome Antigen processing and presentationNOD-like receptor signaling pathwayProgesterone-mediated oocyte maturationPathways in cancerProstate cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Hsp90 alpha antibody [EPR3953]; All lanes : Anti-Hsp90 alpha antibody [EPR3953] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 85 kDa.Observed band size : 90 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in paraffin-embedded Human gastric adenocarcinoma tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in paraffin-embedded Human kidney tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - Hsp90 alpha antibody [EPR3953]; TA307632, at 1/100, staining Hsp90 alpha in HeLa cells by Immunofluorescence.

 

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