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Anti-HNRNPC Antibody EP3034Y
Also for HNRNPC (NM_004500)
|A synthetic peptide corresponding to residues near the N-terminus of human hnRNP C1/C2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:50000 - 1:100000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRNPC), transcript variant 2|
|C1; C2; HNRNP; HNRPC; SNRPC|
|Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a variety of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover (1). hnRNP C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation (2). A novel nuclear export is activated by the ROCK signaling pathway to exclude hnRNP C1/C2 from the nucleus, by which the compartmentalization of specific hnRNP components is disturbed in apoptotic cells (3). Overexpression of hnRNP C1/C2 in hepatocellular carcinoma (HCC) tissues has been reported in 70 HCC samples, suggesting its potential as a protein tumor marker (4). |
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Western blot - hnRNP C1 + C2 antibody [EP3034Y]; All lanes : Anti-hnRNP C1 + C2 antibody [EP3034Y] at 1/100000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : MCF7 cell lysate.Lane 4 : human cerebellum lysate.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 34 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - hnRNP C1 + C2 antibody [EP3034Y]; ab75822 at 1/100 dilution staining hnRNP C1 + C2 in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.