Homo sapiens high mobility group AT-hook 2 (HMGA2), transcript variant 3
BABL, LIPO, HMGIC, HMGI-C;BABL; HMGI-C; HMGIC; LIPO; STQTL9; High-mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; high mobility group AT-hook 2
Peptide with sequence C-KAAQKKAEATGEK, from the interrnal region of the protein sequence according to NP_003474.1; NP_003475.1.
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing. (Protein A or G Sepharose)
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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
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