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Home Antibody All anti-HLA-DMA antibodies

Anti-HLA-DMA Antibody

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SKU Description Amount Price Availability*  
TA308310 Rabbit polyclonal antibody to HLA-DMA (major histocompatibility complex, class II, DM alpha) 100ul $325 3-7 Days
LC416850 HLA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
IHC(1)

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 52 and 245 of HLA-DMA
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Bovine) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 29kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Bovine (83%)

Reference Data

Target NameHomo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA)
Alternative NameD6S222E; DMA; HLADM; RING6
Database LinkNP_006111
Entrez Gene 3108 Human
FunctionHLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq]
Related PathwayTransmembrane Cell adhesion molecules (CAMs)Antigen processing and presentationType I diabetes mellitusAsthmaAutoimmune thyroid diseaseSystemic lupus erythematosusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HLA-DMA antibody detects HLA-DMA protein by Western blot analysis. A. 30 ug Jurkat whole cell lysate/extract. B. 30 ug Raji whole cell lysate/extract. 12 % SDS-PAGE. HLA-DMA antibody (TA308310) dilution: 1:500
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Sample (30 ug of whole cell lysate). A: Hela. 12% SDS PAGE. TA308310 diluted at 1:1000.
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Immunohistochemical analysis of paraffin-embedded Breast ca, using HLA-DMA(TA308310) antibody at 1:250 dilution.
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