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Anti-HLA-B Antibody EPR2623(2)
Also for HLA-B (NM_005514)
|A synthetic peptide corresponding to residues in the extracellular domain of human HLA-B was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens major histocompatibility complex, class I, B (HLA-B)|
|AS; HLAB; SPDA1|
|HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide; exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide; exon 4 encodes the alpha3 domain; exon 5 encodes the transmembrane region; and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described (1).|
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Western blot - HLA B7 antibody [EPR2623(2)]; All lanes : Anti-HLA B7 antibody [EPR2623(2)] at 1/1000 dilution.Lane 1 : Jurkat Ramos cell lysate.Lane 2 : HL60 cell lysate.Lane 3 : TF1 cell lysate.Lane 4 : Ramos cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 40 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HLA B7 antibody [EPR2623(2)]; ab109089 at 1/250 dilution staining HLA B7 in Human tonsil by Immunohistochemistry, Paraffin-embedded tissue.