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Home Antibody All anti-HLA-B antibodies

Anti-HLA-B Antibody EP2624

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Specifications Citations (2) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307214
  • Rabbit monoclonal antibody against HLA-B(clone EP2624)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401691) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for HLA-B (NM_005514)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human HLA-B was used as an immunogen.
Clone NameEP2624 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class I, B (HLA-B)
Alternative NameAS; HLAB; SPDA1
Database LinkNP_005505
Entrez Gene 3106 Human
FunctionHLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide; exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide; exon 4 encodes the alpha3 domain; exon 5 encodes the transmembrane region; and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Related PathwayTransmembrane EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationNatural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-MHC class I + HLA B [EP2624] antibody; All lanes : Anti-MHC class I + HLA B [EP2624] antibody at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HL 60 cell lysate .Lane 3 : Jurkat cell lysate .Lane 4 : TF1 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 40 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MHC class I + HLA B [EP2624] antibody; TA307214, at 1/100, staining HLA B in paraffin embedded Human tonsils by Immunohistochemistry.

 

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