Home Antibody All anti-HIP2 antibodies
Also for HIP2 (NM_001111112)
| Peptide with sequence C-SWDVETATELLLSN, from the C Terminus of the protein sequence according to NP_005330.|
|Test: Human. Expected from seq similarity: Human, Mouse, Dog, Pig, Cow
||ELISA: 1:2,000. WB: 1-3 µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens ubiquitin-conjugating enzyme E2K (UBE2K), transcript variant 2|
|E2-25K; HIP2; HYPG; LIG; UBC1|
Entrez Gene 3093 Human
Entrez Gene 53323 Mouse
Entrez Gene 609531 Dog
|The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]. |
|Transcription FactorsDruggable Genome Ubiquitin mediated proteolysis|
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TA302847 staining (1.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.