Home Antibody All anti-HINT1 antibodies
Also for HINT1 (NM_005340)
|HINT1 antibody was raised against a 17 amino acid peptide near the center of the human HINT1.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, ICC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens histidine triad nucleotide binding protein 1 (HINT1), transcript variant 1|
|HINT; NMAN; PKCI-1; PRKCNH1|
|Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and –hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5’-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.|
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Western blot analysis of HINT1 in Jurkat lysate with HINT1 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of HINT1 in Jurkat cells with HINT1 antibody at 2.5 ug/mL.