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Home Antibody All anti-HAAO antibodies

Anti-HAAO Antibody

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SKU Description Amount Price Availability*  
TA306802
  • Rabbit Polyclonal HAAO Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415914) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)

OriGene Data

ImmunogenHAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens 3-hydroxyanthranilate 3,4-dioxygenase (HAAO)
Alternative Name3-HAO; HAO
Database LinkNP_036337
Entrez Gene 23498 Human
Entrez Gene 107766 Mouse
Entrez Gene 56823 Rat
FunctionHAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Related Pathway Tryptophan metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 ug/ml.
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Immunohistochemistry of HAAO in human liver tissue with HAAO antibody at 2.5 ug/ml.
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