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Anti-GRIN1 PHOSPHO Antibody EPR2480Y
Also for GRIN1 (NM_000832)
|A phospho specific peptide corresponding to residues surrounding serine 889 of human NMDAR1 was used as an immunogen. This antibody detects NMDAR1 phosphorylated at serine 889.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1: 1000; IHC: 1: 100~250; ICC: 1: 100~250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-1|
|GluN1; MRD8; NMDA1; NMDAR1; NR1|
|The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1). A variety of studies have suggested that protein phosphorylation of NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation. PKC phosphorylation occurs on several distinct sites on the NR1 subunit. Most of these sites are contained within a single alternatively spliced exon in the C-terminal domain, which has previously been proposed to be on the extracellular side of the membrane (1). A role for NMDAR1 in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of neurochemical studies in HD and the ability of the NMDAR1 to mediate neuronal cell death (2). Also, studies reveal a unrecognized role of the NMDAR1 in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain (3). |
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Western blot - NMDAR1 (phospho S889) antibody [EPR2480Y]; All lanes : Anti-NMDAR1 (phospho S889) antibody [EPR2480Y] at 1/2000 dilution.Lane 1 : mouse brain lysate, cells untreated.Lane 2 : mouse brain lysate, cells treated with AP.Lysates/proteins at 10 µg per lane.Secondary.HRP-conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 105 kDa.Observed band size : 105 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NMDAR1 (phospho S889) antibody [EPR2480Y]; Immunohistochemical analysis of paraffin-embedded human brain tissue using TA301184 at a dilution of 1/100 - 1/250.