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Home Antibody All anti-GRIN1 antibodies

Anti-GRIN1 PHOSPHO Antibody EPR2480Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301184
  • Rabbit Monoclonal Antibody against GRIN1 (Clone EPR2480Y) (Phospho-specific)
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for GRIN1 (NM_000832)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 889 of human NMDAR1 was used as an immunogen. This antibody detects NMDAR1 phosphorylated at serine 889.
Clone NameEPR2480Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 1000; IHC: 1: 100~250; ICC: 1: 100~250
Predicted MW Explanation 105 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-1
Alternative NameGluN1; MRD8; NMDA1; NMDAR1; NR1
Database LinkNP_000823
Entrez Gene 2902 Human
Entrez Gene 14810 Mouse
Entrez Gene 24408 Rat
FunctionThe NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1). A variety of studies have suggested that protein phosphorylation of NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation. PKC phosphorylation occurs on several distinct sites on the NR1 subunit. Most of these sites are contained within a single alternatively spliced exon in the C-terminal domain, which has previously been proposed to be on the extracellular side of the membrane (1). A role for NMDAR1 in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of neurochemical studies in HD and the ability of the NMDAR1 to mediate neuronal cell death (2). Also, studies reveal a unrecognized role of the NMDAR1 in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain (3).
Related PathwayTransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Calcium signaling pathwayNeuroactive ligand-receptor interactionLong-term potentiationAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - NMDAR1 (phospho S889) antibody [EPR2480Y]; All lanes : Anti-NMDAR1 (phospho S889) antibody [EPR2480Y] at 1/2000 dilution.Lane 1 : mouse brain lysate, cells untreated.Lane 2 : mouse brain lysate, cells treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP-conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 105 kDa.Observed band size : 105 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NMDAR1 (phospho S889) antibody [EPR2480Y]; Immunohistochemical analysis of paraffin-embedded human brain tissue using TA301184 at a dilution of 1/100 - 1/250.

 

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