Home Antibody All anti-GRB10 antibodies
Anti-GRB10 Antibody Polyclonal
Also for GRB10 (NM_005311)
|GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
|GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.|
|GRB10 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens growth factor receptor-bound protein 10 (GRB10), transcript variant 1|
|Grb-10; GRB-IR; IRBP; MEG1; RSS|
|GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.|
EGFR1 Signaling Pathway
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Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of GRB10 in rat brain cells with GRB10 antibody at 20 ug/mL.