Home Antibody All anti-GPR44 antibodies
Also for GPR44 (NM_004778)
|CRTH2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human CRTH2.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens prostaglandin D2 receptor 2 (PTGDR2)|
|CD294; CRTH2; DL1R; DP2; GPR44|
|The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.|
Signaling by GPCR
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Western blot analysis of CRTH2 in Jurkat cell lysate with CRTH2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.
Immunohistochemistry of CRTH2 in human heart tissue with CRTH2 antibody at 2.5 ug/ml.