Home Antibody All anti-GPAM antibodies
Also for GPAM (NM_020918)
|GPAT1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPAT1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), transcript variant 2|
Entrez Gene 57678 Human
Entrez Gene 14732 Mouse
Entrez Gene 29653 Rat
|Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.|
| Glycerolipid metabolismGlycerophospholipid metabolismMetabolic pathways|
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Western blot analysis of GPAT1 in rat brain tissue lysate with GPAT1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of VGF in human brain with VGFantibody at 5 ug/ml.