Home Antibody All anti-GNRHR antibodies
Also for GNRHR (NM_000406)
|Peptide with sequence C-QKWTQKKEKGK, from the internal region of the protein sequence according to NP_000397.1; NP_001012781.1.|
|Test: Human. Expected from seq similarity: Human, Dog
||ELISA: 1:32,000. WB: 0.5-1.5µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens gonadotropin-releasing hormone receptor (GNRHR), transcript variant 1|
|GNRHR1; GRHR; HH7; LHRHR; LRHR|
Entrez Gene 2798 Human
Entrez Gene 403718 Dog
|This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq]. |
|GPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interactionGnRH signaling pathway|
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TA302503 (0.5µg/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.