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Home Antibody All anti-GCG antibodies

Anti-GCG Antibody EPR3070

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SKU Description Amount Price Availability*  
TA307484
  • Rabbit monoclonal antibody against Glucagon(clone EPR3070)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419562) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IHC(5)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Glucagon was used as an immunogen.
Clone NameEPR3070 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:2000; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens glucagon (GCG)
Alternative NameGLP1; GLP2; GRPP
Database LinkNP_002045
Entrez Gene 2641 Human
FunctionGlucagon is an important hormone involved in glucose metabolism and homeostasis (1). It is synthesized and released by the alpha-cells of the islets of Langerhans in pancreas as the proglucagon and is preteolytically processed to yield the mature peptide (2). When the glucose level in the blood is low (hypoglycemia), Glucagon is released and binds to glucagon receptors on hepatocytes, causing the liver to release glucose through glycogenolysis. Upon the depletion of stored glycogen in the liver, Glucagon then stimulates liver to synthesize additional glucose by gluconeogenesis. It strongly opposes the action of insulin. It plays an important role in initiating and maintaining hyperglycemic conditions in diabetes (3).
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Glicentin antibody [EPR3070]; Anti-Glucagon antibody [EPR3070] at 1/2000 dilution + Glucagon recombinant protein at 10 ug.Predicted band size : 21 kDa.
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Other-Anti-Glucagon antibody [EPR3070](TA307484); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Glicentin antibody [EPR3070]; TA307484, at 1/100 dilution, staining Glucagon in paraffin-embedded Human pancreas tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Glucagon antibody [EPR3070](TA307484); TA307484 showing negative staining in Skeletal muscle tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Glucagon antibody [EPR3070](TA307484); TA307484 showing negative staining in Normal lung tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Glucagon antibody [EPR3070](TA307484); TA307484 showing negative staining in Normal kidney tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EPR3070]; TA307484 showing negative staining in Normal brain tissue.
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