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Home Antibody All anti-GAP43 antibodies

Anti-GAP43 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310516
  • Rabbit Polyclonal antibody against GAP43 (C-term)
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human GAP-43 was used as an immunogen.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1,000-10,000;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens growth associated protein 43 (GAP43), transcript variant 1
Alternative NameB-50; PP46
Database LinkNP_001123536
FunctionGrowth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phosphorylated at Ser41 by protein kinase C (PKC), phosphorylated GAP43 has been correlated to release of neurotransmitters in the mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). This suggests GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Anti-GAP43 antibody (TA310516) at 1/1000 dilution + SH-SY-5Y cells lysate at 10 µg. Secondary: HRP labelled goat anti-rabbit at 1/2000 dilution.
IHC Image
Immunohistochemical analysis of paraffin embedded Human astrocytoma tissue labelling GAP43 with TA310516 at a dilution of 1/250.
IF Image
Immunofluorescent analysis of PC12 cells labelling GAP43 with TA310516 at a 1/250 dilution.

 

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