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Anti-GAP43 Antibody Polyclonal
Also for GAP43 (NM_001130064)
|A synthetic peptide corresponding to residues in the C-term of human GAP-43 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens growth associated protein 43 (GAP43), transcript variant 1|
|Growth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phosphorylated at Ser41 by protein kinase C (PKC), phosphorylated GAP43 has been correlated to release of neurotransmitters in the mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). This suggests GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).|
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Anti-GAP43 antibody (TA310516) at 1/1000 dilution + SH-SY-5Y cells lysate at 10 µg. Secondary: HRP labelled goat anti-rabbit at 1/2000 dilution.
Immunohistochemical analysis of paraffin embedded Human astrocytoma tissue labelling GAP43 with TA310516 at a dilution of 1/250.
Immunofluorescent analysis of PC12 cells labelling GAP43 with TA310516 at a 1/250 dilution.