Home Antibody All anti-Fkbp8 antibodies
Also for Fkbp8 (NM_012181)
|Synthetic peptide surrounding amino acid 344 of mouse FKBP38|
|Human, mouse, rat
|100 µg (0.2mg/ml) protein A purified rabbit anti-FKBP38 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 20% glycerol, and 0.02% thimerosal.|
|Homo sapiens FK506 binding protein 8, 38kDa (FKBP8)|
Entrez Gene 23770 Human
Entrez Gene 14232 Mouse
Entrez Gene 290652 Rat
|FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes. |
|TransmembraneDruggable Genome |
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Western blot analysis of FKBP-38 with mouse intestine tissue lysate (left lane) and Jurkat cell lysate (Right lane).