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Home Antibody All anti-Fkbp8 antibodies

Anti-Fkbp8 Antibody

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SKU Description Amount Price Availability*  
TA318946
  • Rabbit polyclonal anti-FKBP38 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415928) , 20ug
100ug 325 In Stock
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WB(1)

OriGene Data

ImmunogenSynthetic peptide surrounding amino acid 344 of mouse FKBP38
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat Concentration0.2mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4ug/ml
Buffer100 µg (0.2mg/ml) protein A purified rabbit anti-FKBP38 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 20% glycerol, and 0.02% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens FK506 binding protein 8, 38kDa (FKBP8)
Alternative NameFKBP38; FKBPr38
Database LinkNP_036313
FunctionFK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
Related Pathway

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WB Image
Western blot analysis of FKBP-38 with mouse intestine tissue lysate (left lane) and Jurkat cell lysate (Right lane).

 

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