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Home Antibody All anti-FOXO4 antibodies

Anti-FOXO4 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319683
  • Rabbit Polyclonal FOXO4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401798) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenFOXO4 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FOXO4.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferFOXO4 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification FOXO4 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens forkhead box O4 (FOXO4), transcript variant 2
Alternative NameAFX; AFX1; MLLT7
Database LinkNP_001164402
FunctionFOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot analysis of FOXO4 in HeLa cell lysate with FOXO4 antibody at (A) 0.5 and (B) 1 ug/mL.
IF Image
Immunocytochemistry of FOXO4 in HeLa cells with FOXO4 antibody at 10 ug/mL.

 

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