Anti-FOXO4 Antibody, EPR2314(2)

Also for FOXO4 (NM_001170931)

OriGene Data

Immunogen	A phospho specific peptide corresponding to residues surrounding Threonine 32 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at Threonine 32.
Clone Name	EPR2314(2)	Isotype
Species Reactivity	Human	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens forkhead box O4 (FOXO4), transcript variant 2
Alternative Name	AFX; AFX1; MLLT7
Database Link	NP_001164402
Function	FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).
Related Pathway	TGF Beta Signaling Pathway

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WB Image

Western blot analysis on (A) 293T, (B) 293T transfected with HA-FOXO4, and (C) 293T transfected with HA-FOXO4.A3 (T32, S197 and S262 mutated to A) cell lysates using anti-Phospho-FOXO4 (pT32) RabMAb.

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-FOXO4 Phospho Antibody EPR2314(2)

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data