Home All anti-FOXO4 antibodies
Anti-FOXO4 Phospho Antibody EPR2314(2)
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Also for FOXO4 (NM_001170931)
|A phospho specific peptide corresponding to residues surrounding Threonine 32 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at Threonine 32.|
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens forkhead box O4 (FOXO4), transcript variant 2|
|AFX; AFX1; MLLT7|
|FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2). |
TGF Beta Signaling Pathway
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Western blot analysis on (A) 293T, (B) 293T transfected with HA-FOXO4, and (C) 293T transfected with HA-FOXO4.A3 (T32, S197 and S262 mutated to A) cell lysates using anti-Phospho-FOXO4 (pT32) RabMAb.