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Home Antibody All anti-FOXO4 antibodies

Anti-FOXO4 PHOSPHO Antibody EPR2314(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310502
  • Rabbit Monoclonal antibody against FOXO4, pT32 (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for FOXO4 (NM_005938)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Threonine 32 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at Threonine 32.
Clone NameEPR2314(2) IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens forkhead box O4 (FOXO4), transcript variant 1
Alternative NameAFX; AFX1; MLLT7
Database LinkNP_005929
FunctionFOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - Anti-FOXO4 (phospho T32) antibody [EPR2314(2)]; All lanes : Anti-FOXO4 (phospho T32) antibody [EPR2314(2)] at 1/1000 dilution.Lane 1 : 293T cell lysates.Lane 2 : 293T transfected with HA-FOXO4 cell lysates.Lane 3 : 293T transfected with HA-FOXO4.A3 (T32, S197 and S262 mutated to A) cell lysates.Predicted band size : 53 kDa.
Assay Image
Other-Anti-FOXO4 (phospho T32) antibody [EPR2314(2)](TA310502); Equilibrium disassociation constant (KD)..

 

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