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Anti-FOXO4 PHOSPHO Antibody EPR2314(2)
Also for FOXO4 (NM_005938)
|A phospho specific peptide corresponding to residues surrounding Threonine 32 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at Threonine 32.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Is unsuitable for IHC-P or IP.
|Homo sapiens forkhead box O4 (FOXO4), transcript variant 1|
|AFX; AFX1; MLLT7|
Entrez Gene 4303 Human
|FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2). |
|Transcription Factors |
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Western blot - Anti-FOXO4 (phospho T32) antibody [EPR2314(2)]; All lanes : Anti-FOXO4 (phospho T32) antibody [EPR2314(2)] at 1/1000 dilution.Lane 1 : 293T cell lysates.Lane 2 : 293T transfected with HA-FOXO4 cell lysates.Lane 3 : 293T transfected with HA-FOXO4.A3 (T32, S197 and S262 mutated to A) cell lysates.Predicted band size : 53 kDa.
Other-Anti-FOXO4 (phospho T32) antibody [EPR2314(2)](TA310502); Equilibrium disassociation constant (KD)..