The Fos family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. Fra-1, known as Fos-related Antigen 1 or FOSL1, is a leucine zipper protein that can dimerize with JUN family proteins, thereby forming the transcription factor complex AP-1. As such, Fra-1 has been implicated as regulators of cell proliferation, differentiation, and transformation (1).
Wnt Signaling Pathway
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