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Home Antibody All anti-FLT3 antibodies

Anti-FLT3 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319653
  • Rabbit Polyclonal FLT3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418194) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for FLT3 (NM_004119)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, IF: 20 ug/ml
Predicted MW Explanation 109 kDa
BufferFLT3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification FLT3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens fms-related tyrosine kinase 3 (FLT3)
Alternative NameCD135; FLK-2; FLK2; STK1
Database LinkNP_004110
Entrez Gene 2322 Human
Entrez Gene 14255 Mouse
FunctionFLT3 Antibody: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.
Related PathwayProtein KinaseES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionHematopoietic cell lineagePathways in cancerAcute myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of FLT3 in 3T3 cell lysate with FLT3 antibody at (A) 1 and (B)2 ug/mL.
IF Image
Immunofluorescence of FLT3 in human kidney tissue with FLT3 antibody at 20 ug/mL.

 

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