Home Antibody All anti-FKBP4 antibodies
Also for FKBP4 (NM_002014)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 177 of FKBP52|
|WB, IHC, IF
||WB:1:1000-1:10000; IHC:1:500; IF:1:100-1:500;
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens FK506 binding protein 4, 59kDa (FKBP4)|
|FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase|
Entrez Gene 2288 Human
Entrez Gene 14228 Mouse
|The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq]|
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A: H1299 (anti-FKBP4 antibody diluted at 1:5000)
A: Mouse brain (anti-FKBP4 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using FKBP52(anti-FKBP4 antibody) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed A431, using FKBP52(anti-FKBP4 antibody) antibody at 1:200 dilution.