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Anti-FKBP1A Antibody EPR3888
Also for FKBP1A (NM_000801)
|A synthetic peptide corresponding to residues at the C-terminus in human FKBP12 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:50 - 100, WB: 1:10,000 - 50,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1|
|FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE|
|FKBP12 (Fkbp1a) is a member of the FK-506-binding protein (FKBP) family. This family of proteins possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity and is believed to play an important role in accelerating the rate at which proteins fold into their native conformations (1). FKBP12 was originally identified as a cytosolic receptor for the immunosuppressant drugs, FK506 and rapamycin, and later shown to be involved in cell-cycle regulation and in intracellular calcium homeostasis. Binding of FKBP12 to rapamycin through its FK506/rapamycin-binding/ PPIase domain mediates the immunosuppressive and anti-tumor effects of rapamycin, a drug that has shown to arrest tumor cells in G1 phase of the cell cycle and to reduce tumor angiogenesis (2). FKBP12 is highly conserved from yeast through human and is relatively abundant in most tissues and cell types (3).|
TGF Beta Signaling Pathway
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Western blot - FKBP12 antibody [EPR3888]; All lanes : Anti-FKBP12 antibody [EPR3888] at 1/10000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : U937 cell lysate.Lane 3 : SH-SY5Y cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 12 kDa.