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Home Antibody All anti-FKBP1A antibodies

Anti-FKBP1A Antibody EPR3888

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307667
  • Rabbit monoclonal antibody against FKBP12(clone EPR3888)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400279) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for FKBP1A (NM_000801)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus in human FKBP12 was used as an immunogen.
Clone NameEPR3888 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsICC: 1:50 - 100, WB: 1:10,000 - 50,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1
Alternative NameFKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
Database LinkNP_000792
FunctionFKBP12 (Fkbp1a) is a member of the FK-506-binding protein (FKBP) family. This family of proteins possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity and is believed to play an important role in accelerating the rate at which proteins fold into their native conformations (1). FKBP12 was originally identified as a cytosolic receptor for the immunosuppressant drugs, FK506 and rapamycin, and later shown to be involved in cell-cycle regulation and in intracellular calcium homeostasis. Binding of FKBP12 to rapamycin through its FK506/rapamycin-binding/ PPIase domain mediates the immunosuppressive and anti-tumor effects of rapamycin, a drug that has shown to arrest tumor cells in G1 phase of the cell cycle and to reduce tumor angiogenesis (2). FKBP12 is highly conserved from yeast through human and is relatively abundant in most tissues and cell types (3).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - FKBP12 antibody [EPR3888]; All lanes : Anti-FKBP12 antibody [EPR3888] at 1/10000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : U937 cell lysate.Lane 3 : SH-SY5Y cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 12 kDa.

 

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