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Anti-FIG4 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for FIG4 (NM_014845)
|DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|ELISA, IHC, IF
||WB: 1:500; ELISA: 1:100-1:2000; IHC: 1:300; IF: 1:25
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens FIG4 phosphoinositide 5-phosphatase (FIG4)|
|ALS11; BTOP; CMT4J; dJ249I4.1; KIAA0274; SAC3; YVS|
Entrez Gene 9896 Human
|The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.|
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Immunohistochemistry: FIG4 Antibody - Most of the normal tissues displayed moderate to strong cytoplasmic positivity which was occasionally accompanied with nuclear staining. Malignant tissues exhibited in most cases moderate cytoplasmic immunoreactivity. Strong staining was observed in several tumors but was most prominent in colo-rectal and stomach cancers. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human duodenum shows strong positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.
Immunofluorescent staining of human cell line U-2 OS shows no positivity.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.