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Home Antibody All anti-FGFR3 antibodies

Anti-FGFR3 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319650 Rabbit Polyclonal FGFR3 Antibody 100ug $325 3-7 Days
LC424902 FGFR3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for FGFR3 (NM_000142)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsELISA, WB: 1 - 2 ug/ml
Predicted MW Explanation Predicted: 89 kDa Observed: 9+2, 98 kDa
BufferFGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification FGFR3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1
Alternative NameACH; CD333; CEK2; HSFGFR3EX; JTK4
Database LinkNP_000133
Entrez Gene 2261 Human
Entrez Gene 14184 Mouse
Entrez Gene 84489 Rat
FunctionFGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).
Related PathwayProtein KinaseTransmembraneDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerBladder cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 antibody at (A) 0.5 and (B) 1 ug/mL.
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