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Anti-FGFR3 Antibody EPR2304(3)
Also for FGFR3 (NM_000142)
|A synthetic peptide corresponding to residues in the extracellular domain of human FGF Receptor 3 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
|WB, ASSAY, FC
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1|
|ACH; CD333; CEK2; HSFGFR3EX; JTK4|
|FGF Receptor 3 is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGF Receptor 3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGF Receptor 3 lead to craniosynostosis and multiple types of skeletal dysplasia (1).|
MAPK signaling pathway
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Western blot - Anti-FGFR3 antibody [EPR2304(3)]; All lanes : Anti-FGFR3 antibody [EPR2304(3)] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Fetal kidney lysate.Lane 3 : K562 lysate.Lane 4 : A549 lysate.Lane 5 : HepG2 lysate.Lane 6 : HeLa lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 88 kDa.
Other-Anti-FGFR3 antibody [EPR2304(3)](ab133644); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-FGFR3 antibody [EPR2304(3)]; Flow cytometry analysis of K562 cells labelling FGFR3 with ab133644 at 1/10 dilution (red). Rabbit IgG (negative) shown in green.