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Home Antibody All anti-FGFR1 antibodies

Anti-FGFR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302994
  • Goat Polyclonal Antibody against FGFR1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402963) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

Immunogen Peptide with sequence CLPRHPAQLANGGLKR, from the C Terminus of the protein sequence according to NP_000595; NP_056934; NP_075593; NP_075594; NP_075599.
Clone Name IsotypeGoat IgG
Species ReactivityHuman Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:32,000. WB: 0.3-1µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) (FGFR1), transcript variant 1
Alternative NameH2, H3, H4, H5, CEK, FLG, FLT2, KAL2, BFGFR, C-FGR, CD331, N-SAM
Database LinkNP_000595
FunctionThe protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq].
Related Pathway
Adherens junction
MAPK signaling pathway

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WB Image
TA302994 (0.3µg/ml) staining of human breast lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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