Home Antibody All anti-FGFR1 antibodies
Also for FGFR1 (NM_023110)
|This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from human FGFR1.|
|Human (Predicted: Mouse, Rat, Chicken)
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|This antibody is purified through a protein A column, followed by peptide affinity purification.
|Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1|
|bFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD|
Entrez Gene 2260 Human
Entrez Gene 14182 Mouse
Entrez Gene 79114 Rat
|FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.|
|Protein KinaseTransmembraneDruggable Genome MAPK signaling pathwayAdherens junctionRegulation of actin cytoskeletonPathways in cancerProstate cancerMelanomaMore Pathways >> |
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Western blot analysis of FGFR1 (arrow) using rabbit polyclonal FGFR1 Antibody (Y463) (RB11175). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2) (Origene Technologies).