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Anti-FGB Antibody EPR3083
|A synthetic peptide corresponding to residues near the C-terminus of in human Fibrinogen beta chain was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000; FC: 1:20; ICC/IF: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens fibrinogen beta chain (FGB), transcript variant 1|
|Fibrinogen beta chain yields monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. Defects in FGB are a cause of thrombophilia. Defects in FGB are a cause of congenital afibrinogenemia. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen (1). |
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Western blot - Anti-Fibrinopeptide B antibody [EPR3083]; All lanes : Anti-Fibrinopeptide B antibody [EPR3083] at 1/1000 dilution.Lane 1 : Human plasma lysate.Lane 2 : Human prostate lysate.Lane 3 : Rat platelet lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 56 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-Fibrinopeptide B antibody [EPR3083]; Immunofluorescence analysis of Fibrinopeptide B in HeLa cells, using TA307248 at a dilution of 1/100.