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Home Antibody All anti-FEZ1 antibodies

Anti-FEZ1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306444
  • Rabbit Polyclonal FEZ1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417518) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenFEZ1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FEZ1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens fasciculation and elongation protein zeta 1 (zygin I) (FEZ1), transcript variant 1
Alternative Namezygin 1; fasciculation and elongation protein zeta 1 (zygin I)
Database LinkNP_005094
FunctionSimilar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE.
Related Pathway

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WB Image
Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 µg/ml in the (A) presence and (B) absence of blocking peptide.

 

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