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Home Antibody All anti-FES antibodies

Anti-FES Antibody EPR3230(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307577
  • Rabbit monoclonal antibody against FES(clone EPR3230(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC428344) , 20ug
100ul $325 3-7 Days
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WB(1)
IF(1)
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Also for FES (NM_001143783)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FES was used as an immunogen.
Clone NameEPR3230(2) IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:100 - 1:500; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens feline sarcoma oncogene (FES), transcript variant 2
Alternative NameFPS
Database LinkNP_001137255
FunctionFES is a non-receptor protein-tyrosine kinase implicated in myeloid, vascular endothelial and neuronal cell differentiation. Closely related to FER, FES is characterized by a unique amino-terminal region (critical for kinase regulation and downstream signaling), a central SH2 domain, and a carboxyl-terminal kinase domain (1, 2). FES lacks an SH3 domain, a negative regulatory tail, and other features that contribute to negative regulation of c-Src, c-Abl, and other cytoplasmic tyrosine kinases. FES activation in response to growth factors and cytokines has been linked to various cellular events including survival, proliferation, differentiation, and reorganization of the cytoskeleton. FES has been implicated as a tumor suppressor in colorectal cancer (3).
Related Pathway

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WB Image
Western blot - FES antibody [EPR3230(2)]; All lanes : Anti-FES antibody [EPR3230(2)] at 1/1000 dilution.Lane 1 : TF-1 lysate.Lane 2 : U937 lysate.Lane 3 : Human spleen lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 93 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - FES antibody [EPR3230(2)]; TA307577, at a 1/100 dilution, staining FES in HeLa cells by Immunofluorescence.

 

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